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br Acknowledgements br Introduction The chronic
2019-04-23

Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–
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br Role of the funding
2019-04-23

Role of the funding source Introduction Myeloproliferative neoplasms (MPNs) are stem-cell-derived disorders that cause overproduction of one or more of the formed elements of the blood. MPNs include chronic myelogenous leukemia (CML) and the Philadelphia-negative MPNs: polycythemia vera (PV),
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br is a bacterial infection causing necrotising lesions of s
2019-04-23

is a bacterial infection causing necrotising lesions of skin and subcutaneous tissue. Widely known as Buruli ulcer, it is classified as a neglected tropical disease by WHO. If diagnosed and treated early, outcomes are good, but if left untreated it can progress to a severe disease resulting in hig
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In the past two decades several studies have consistently fo
2019-04-23

In the past two decades, several studies have consistently found that up to one-sixth of cancers worldwide are attributable to infectious pathogens. Cancers caused by infectious agents present unique opportunities for prevention and treatment; therefore, a detailed understanding of how infections co
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Ante la falta de un ambiente
2019-04-22

Ante la falta de un ambiente estimulante para la producción de un pensamiento crítico y una conciencia social, Pablo Molinet (1975) escribe: “Quizá nuestra época nos dejó hablando solos” (93). No es de extrañar: luego de 1968, las concentraciones de jóvenes fueron vistas como un peligro y se dispuso
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Assim como em rela o a Cuba os editores
2019-04-22

Assim como em relação sodium channel Cuba, os editores da revista Araucaria de Chile retomaram personagens históricos de modo a compor as representações sobre a Nicarágua revolucionária. Novamente, um poema do comunista Pablo Neruda foi publicado postumamente na revista, desta vez feito em homenagem
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The number of residents in London
2019-04-22

The number of residents in London who were originally from the 21 endemic countries in Central and South America was calculated from the 2011 UK National Census and was stratified by borough. We did not include undocumented migrants and individuals born to mothers from endemic Latin American countri
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br Discussion Appendicitis is seen in the general population
2019-04-22

Discussion Appendicitis is seen in the general population with a lifetime cumulative incidence rate of 9% [7]. Our calculated incidence rate of appendicitis in the setting of acute leukemia (1.9%) correlates with the reported incidence of 0.5–4.4% [1]. Leukemic involvement of the gastrointestinal
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vegf tyrosine kinase inhibitor br Discussion There is an imp
2019-04-22

Discussion There is an important need for new treatment options for AML in elderly patients. Their frailty imposes limitations upon the aggressiveness of the treatment which can be administered [6,24]. In addition, the poor prognostic disease features often seen in this vegf tyrosine kinase inhib
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LY335979 Supplier In Alexandre de Figueiredo and colleagues
2019-04-22

In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when LY335979 Supplier coverage might
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Human p MAPK is stimulated by various
2019-04-22

Human p38 MAPK is stimulated by various inflammatory cytokines and cellular stresses [46]. Especially, the p38 MAPK signaling pathway is a crucial modulator of proinflammatory cytokine biosynthesis at the transcriptional and translational levels [46]. Furthermore, studies revealed that p38 MAPK regu
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br Case A year old man was referred for the
2019-04-22

Case A 45-year-old man was referred for the management of sudden-onset tachycardia. He had experienced 3 episodes of palpitation attacks, lasting for a couple of hours each, during the last 6 months. A regular, wide QRS complex tachycardia (WCT) at 150beats/min with a prominent retrograde P wave
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br Methods br Results br
2019-04-22

Methods Results Discussion Conclusions Conflict of interest Acknowledgments We thank Mr. John Martin for his linguistic assistance, and Mr. Jiro Suto for technical assistance in developing the QRS-T subtraction program. This study was supported by the Fukuda Foundation for Medical
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The first variant in the non spine topic describes a
2019-04-22

The first variant in the non-spine topic describes a patient with an excellent performance status, a favorable life expectancy, and an asymptomatic mCAP lesion which does not pose an obvious risk for pathologic fracture. While the authors acknowledge that research has begun to determine whether pati
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Several anti platelet therapies have been evaluated in the c
2019-04-22

Several anti-platelet therapies have been evaluated in the context of bone metastasis. In vitro, a dual anti-platelet treatment using the soluble ADPase APT102 and an inhibitor of TxA2 synthesis (Aspirin) markedly affected tumor cell-induced platelet aggregation without altering tumor cell viability
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